Year: 2017 | Month: December | Volume 5 | Issue 2
Isochorismate Synthase (MenF) - 3D Prediction in Mycobacterium Tuberculosis: A Potential Drug Target
DOI:10.5958/2321-7111.2017.00013.0
Abstract:
In fastest Developing countries, disease burden make an unhealthy and undeveloped. It is still challenge to prevent Tuberculosis (TB) even though lot of preventable and curable measurements taken up by both state and central governments in India. In this context we are focused to explore the new 3D drug target structurally and functionally by using bioinformatics tool. We searched the new drug target by comparative search analysis in KEGG data base (previous work not published). One of the new drug target Isochorismatesynthase (MenF) was selected and performed sequence alignment, Homology Modeling, validation and performed secondary structure analysis. Moduller results showed that the 3D-Model is accurate and accepted model. Validation of 3D model is confirmed that, there is 99.03% amino acids are in allowed and generously allowed region of Ramachandran plot, this can be useful for further steps in the insilico research. ProsA analysis provides the local and over all model quality within the Z scores limits. Pdb sum analysis provided the main chain, side chain and active site residues. This clearly explains the utilization of bioinformatics tools in the process of drug development to young researchers.
© This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Print This Article Email This Article to Your Friend
